YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Preventive Effect of Fursulthiamine on Dietary Hypertension in Rats

Fursulthiamine이 흰쥐의 식이성 고혈압에 대한 예방효과

  • 이은방 (서울대학교 천연물과학연구소) ;
  • 이영순 (서울대학교 천연물과학연구소) ;
  • 김옥경 (대진대학교 이공대학)
  • Published : 1999.02.01
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Abstract

Dietary hypertension induced by feeding cholesterol and vitamin D3 in rats for 7 weeks was prevented by the addition of fursulthiamine and diallyl disulfide in the diet. In the isolated preparation of the hypertentive rats, the contractile forces were potentiated by norepinephrine, serotonin and potassium chloride, as compared to that of the normotensive rats. However, the increased contractile forces of the hypertensive rats were inhibited in the aorta of the rats fed with fursulthiamine. Decreases in triglyceride contents were observed in the sera of the hypertensive rats fed with fursulthiamine. Therefore, it is suggested that dietary hypertension in rats may be prevented by supplement of fursulthiamine in the diet.

Keywords

References

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