Archives of Pharmacal Research
- 제22권2호
- /
- Pages.202-207
- /
- 1999
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis and Biological Studies of Catechol Ether Type Derivatives as Potential Phosphodiesterase (PDE) IV Inhibitors
- Rhee, Chung K. (Department of Medicinal Chemistry, R&D Center, Cheil Jedang Corp.) ;
- Kim, Jong-Hoon (Department of Medicinal Chemistry, R&D Center, Cheil Jedang Corp.) ;
- Suh, Byung-Chul (Department of Medicinal Chemistry, R&D Center, Cheil Jedang Corp.) ;
- Xiang, Myung-Xik (Department of Medicinal Chemistry, R&D Center, Cheil Jedang Corp.) ;
- Youn, Yong-Sik (Department of Medicinal Chemistry, R&D Center, Cheil Jedang Corp.) ;
- Bang, Won-Young (Department of Pharmacology, R&D Center, Cheil Jedang Corp.) ;
- Kim, Eui-Kyung (Department of Pharmacology, R&D Center, Cheil Jedang Corp.) ;
- Shin, Jae-Kyu (Department of Pharmacology, R&D Center, Cheil Jedang Corp.) ;
- Lee, Youn-Ha (Department of Pharmacology, R&D Center, Cheil Jedang Corp.)
- 발행 : 1999.04.01
초록
New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is ap preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with studies with synthetic compounds will be discussed in detail.
키워드