Archives of Pharmacal Research
- 제22권1호
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- Pages.86-88
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Advanced Method for Determination of Omeprazole in Plasma by HPLC
- Kang, Won-Ku (College of Pharmacy, Chungnam National University) ;
- Kim, Dong-Sup (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Kwon, Dwang-Il (College of Pharmacy, Chungnam National University)
- 발행 : 1999.02.01
초록
An advance d and sensitive high-performance liquid chromatographic (HPLC) method for determination of omeparzole in human plasma has been developed. After omeprazole was extracted from plasma with diethylether, the organic phase was transferred to another tube and trapped back with 0.1 N NaOH solution. The alkaline aqueous layer was injected into a reversed-phase C8 column. Lansoprazole was used as an internal standard. The mobile phase consisted of 30% of acetonitrile and 70% of 0.2 M