Archives of Pharmacal Research

  • 제22권1호
  • /
  • Pages.75-77
  • /
  • 1999
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Inhibitory Constituents against HIV-1 Protease from Agastache rugosa

  • Min, Byung-Sun (College of Pharmacy, Chungnam National University/Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University) ;
  • Masao-Hattori (Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University) ;
  • Lee, Hyeong-Kyu (Korea Research Institute of Bioscience & Botechnology) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University)
  • 발행 : 1999.02.01
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초록

Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with $IC_{50}$ values of 360 and $87{\mu}M$, respectively.

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