Archives of Pharmacal Research
- 제22권1호
- /
- Pages.48-54
- /
- 1999
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Nitric Oxide Synthase Inhibitor Decreases NMDA-Induced Elevations of Extracellular Glutamate and Intracellular $Ca^{2+}$ Levels Via a cGMP-Independent Mechanism in Cerebellar Granule Neurons
- Oh, Sei-Kwan (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
- Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
- Ryoo, In-Ja (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
- Patrick P.McCaslin (Department of Anesthesia School of Medicine, Wake Forest University) ;
- Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator)
- 발행 : 1999.02.01
초록
These studies were designed to examine the differential effect of nitric oxide (NO) and cGMP on glutamate neurotransmission. In primary cultures of rat cerebellar granule cells, the glutamate receptor agonist N-methyl-D-aspartate (NMDA) stimulates the elevation of intracellular calcium concentration (
키워드