Archives of Pharmacal Research
- Volume 22 Issue 1
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- Pages.48-54
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Nitric Oxide Synthase Inhibitor Decreases NMDA-Induced Elevations of Extracellular Glutamate and Intracellular $Ca^{2+}$ Levels Via a cGMP-Independent Mechanism in Cerebellar Granule Neurons
- Oh, Sei-Kwan (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
- Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
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Ryoo, In-Ja
(Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator) ;
- Patrick P.McCaslin (Department of Anesthesia School of Medicine, Wake Forest University) ;
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Yoo, Ick-Dong
(Korea Research Institute of Bioscience and Biotechnology, Cell Fuction Regulator)
- Published : 1999.02.01
Abstract
These studies were designed to examine the differential effect of nitric oxide (NO) and cGMP on glutamate neurotransmission. In primary cultures of rat cerebellar granule cells, the glutamate receptor agonist N-methyl-D-aspartate (NMDA) stimulates the elevation of intracellular calcium concentration (
Keywords
- NMDA;
- $N^G-Monomethyl-L-arginine;
- Dibutyryl-cGMP$;
- 4Ca^{2+} Influx$;
- Hydroxocobalamin;
- Glutamate release