Archives of Pharmacal Research
- Volume 22 Issue 1
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- Pages.44-47
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Analgesic and Anti-inflammatory Activities of 1,2-Benzothiazine Derivatives
-
Lee, Eun-Bang
(Natural Products Research Institute Seoul National University)
;
- Kwon, Soon-Kyoung (College of Pharmacy, Duksung Women's University) ;
- Kim, Sang-Geon (College of Pharmacy, Duksung Women's University)
- Published : 1999.02.01
Abstract
Three 1,2-benzothiazine derivatives were synthesized, and their analgesic / anti-inflammatory efficacy and their effect s of gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent anlagesic action, but the effect was weaker than that of piroxicam. Nonetheless, the compound showed 4 times more potent analgesic action with less gastric damage than did ibuprofen. These compounds did not show anti-inflammatory effect at an oral dose of 5 mg/kg.