A PROMISING NEW ANTI-WRINKLE INGREDIENT: Pericarpium castaneae extracts

  • Kim, Beom-Jun (Skin Biology Laboratory, R&D Center, Coreana Cosmetics Co. Ltd.) ;
  • Jo, Byoung-Kee (Skin Biology Laboratory, R&D Center, Coreana Cosmetics Co. Ltd.) ;
  • Kim, Jeong-Ha (Skin Biology Laboratory, R&D Center, Coreana Cosmetics Co. Ltd.)
  • 발행 : 1999.12.31

초록

Pericarpium castaneae extracts have variously potent activities, such as anti-oxidative activity and free radical scavenging activity. in vivo and in vitro studies both indicate that pericarpium castaneae extracts acts as a free radical scavenger($IC_{50}:7.6{\mu}g/ml$) stronger than gallic acid($IC_{50}:12.5{\mu}g/ml$) and ellagic acid($IC_{50}:15{\mu}g/ml$) which could prevent cutaneous UV damages and skin aging. The extracts showed a good effect as a anti-oxidant($IC_{50}:50{\mu}g/ml$). It was shown that the appearance of wrinkle in human skin was reduced by topical application of pericarpium castaneae extracts. And the treatment of human skin with the extracts increased the elasticity and moisture of the skin. We investigated the effect of the pericarpium castaneae extracts on production of extracellular matrix using cultured A431 fibroblast cells. The results indicated that the extracts had no detectable effect on collagen synthesis. But synthesis of cell adhesion protein was increased by the extracts. The results suggest that increase of cell adhesion protein synthesis by pericarpium castaneae extracts has closely related to reduction of wrinkle in skin.

키워드

참고문헌

  1. Anal. Biochem. v.95 Ohakawa, T.;Ohishi, N.;Yagi, K.
  2. Yakugaku Zasshi v.108 Fugita, Y.;Uera, I.;Morimoto, Y.;Nakajima, M.;Hatano, C.;Okuda, T.
  3. Bioengineering of the skin: Methods and instrumentation:CRC Skin elasticity Elsner, P.;Berardesca, E.;Elsner, P.;Wilhelem, K.P.;Maribach, H.I.(eds.)
  4. Comparative studies of skin roughness measurements by profilometry and a new image analysis system: Cosmetics and toiletries manufacture world wide Nissen, H.P.
  5. Hand-book of non-invasive methods and the skin Stylus method for skin suface contour measurement Gassmueller, J.;Kecskes, A.;Jahn, P.
  6. Oxidative damage and repair Davies, K.T.A.
  7. Mutation Res. v.250 Simic, M.G.;Bergtold, D.S.
  8. Environ. Mol. Mutagen. v.15 Hartman, P.E.;Shankel, D.M.
  9. Cancer Res. v.52 Wattenberg, L.W.
  10. Fragrance J. v.8 Active oxygen scavenging activity in plant extracts Masak, H.
  11. Fragrance J. v.18 Reactive oxygen species scavenging effect of crude drug Fukuda, T.;Kitada, Y.
  12. Chem. Pharm. Bull. v.40 no.8 Yoshikawa, M.;Yamahara, J.