동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제10권2호
  • /
  • Pages.115-126
  • /
  • 1999
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

우황청심원(牛黃淸心元)이 NOS inhibitor에 의한 흰쥐의 학습(學習) 및 기억장애(記憶障碍)에 미치는 영향(影響)

The effect of Woohwangchungsimwon on the learning and memory in NOS inhibitor treated rats in Morris water maze.

  • 백지성 (경희대학교 한의과대학 신경정신과학교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신과학교실) ;
  • 황의환 (경희대학교 한의과대학 신경정신과학교실)
  • Baek Ji-Seong (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • Kim Jong-Woo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • 발행 : 1999.12.30
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초록

This study was conducted to find out the effects of Woohwangchungsimwon on learning and memory in the NOS inhibitor treated rats. The Morris water maze was used in evaluating them. The result of the study was summarized as follows. 1. In the learning test, three groups have showed a gradual improvement of learning ability by repeating the trials in Morris water maze. WHCS group have showed statistical improvement than control group at 4,5,6 trial(p<0.05, p<0.01, p<0.01). 2. In the memory test, the first latency of WHCH group was statistically shortened than that of control group(p<0.05). 3. In the memory test, there was no statistical difference in the entry number between WHCH group and control. 4. In the memory test, there was no statistical difference in the memory score between WHCH group and control. The result of this experimental study presents that Woohwangchungsimwon has the improving effect on impaired learning and memory in NOS inhibitor treated rats, and implies that Woohwangchungsimwon may be one of the useful prescription for the treatment of vascular dementia after cerebral ischemia.

키워드

참고문헌

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