Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지

Effects of Peppermint Oil on Apoptosis of Astrocytes

신경교(神經膠) 성상세포(星狀細胞)의 세포자감사(細胞自減死)에 있어서 박하오일의 효과(效果)

  • Lee Sung-Ryull (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kim Tae-Hun (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • 이성률 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 1999.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Recently, essential oils are used for aromatherapy. Most essential oils are said to be anti-bacterial; some may be anti-viral or anti-fungal. I investigated the effects of peppermint pure essential oil on the heat shock-induced apoptosis in human astrocyte cell line CCF-STTGI. In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3. We studied the heat shock-induced apoptosis through flow cytometry, DNA electrophoresis, and giemsa staining. Interestingly, these events were inhibited by pretreatment of peppermint pure essential oils in CCF-STTGl cells. Peppermint oil also inhibited the heat shock-induced apoptosis in primary cultured rat astrocytes. In addition, this Peppermint essential oil inhibited the heat shock-induced activation of caspase-3. These results suggest that peppermint pure essential oils may modulate the apoptosis through the activation of the interleukin-I -converting enzyme-like protease.

Keywords

References

  1. Annu. Rev. Cell. Biol. v.7 Ellis, R.E.;Yuan, J.;Horvitz, H.R.
  2. Science v.267 Steller, H.
  3. 韓國生化學會 v.5 no.3 老化의 메카니즘과 硏究方向, 生化學뉴스 崔鎭浩
  4. 皮膚科學 大韓皮膚科學會刊行委員會
  5. 成人病, 老人病學 徐舜圭
  6. 東醫精神醫學 黃義完(外)
  7. 黃帝內經素問解釋 洪元植(譯)
  8. 黃帝內經靈樞解釋 洪元植(著)
  9. 臨床本草學 辛民敎
  10. 申氏本草學 申佶求
  11. 中藥大辭典 蘇新醫學院
  12. 아로마테라피 이세희
  13. 大韓韓方內科學會誌 v.19 no.1 養生을 위한 香氣治療의 韓醫學的 適用과 展望 柳永秀(外)
  14. J. Cell. Physiol. v.151 Mosser, D.D.;Martin, L.H.
  15. Int. J. Cancer v.66 Yonezawa, M.;Otsuka, T.;Matsui, N.;Kato, T.
  16. Biochem. J. v.326 Cohen, G.M.
  17. Methods and Achievements in Experimental Pathology. v.4 Trump, B.F.;Ginn, F.L.;Bajusz, E.;Jasmin, G.(eds.)
  18. 이철완교수의 老人病硏究 이철완
  19. 대한정신약물학회지 v.3 no.1 痴呆의 原因과 治療 박종한
  20. 신경정신의학 v.29 no.6 Mattis Dementia Rating Scale(MDRS)의 非癡 呆老人群에 대한 硏究 곽호순(外 2人)
  21. 대한신경과학회지 v.3 no.1 痴呆(Dementia)의 정의와 분류 김명호
  22. 대한정신약물학회지 v.2 no.1 Alzheimer씨 痴呆-개론 및 최신 경향- 김진수
  23. Atlas of clinical neurology 2nd edition G David Perkin;Fred H Hochberg
  24. General and systemic pathology 2nd edition. Underwood, J.C.E.
  25. Medical Neurology 3rd edition John Stirling Meyer
  26. Neurology v.42 no.3 Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers Chui, H.C.;Victoroff, J.I.;Margolin, D.;Jagust, W.;Shankle, R.;Katzman, R.
  27. 精校黃帝內經靈樞 洪元植(編)
  28. 張氏景岳全書 張介賓
  29. 辨證奇門全書 錢鏡湖
  30. 國譯石室秘錄 陣士鐸
  31. 辨證錄 陳士鐸
  32. 編註醫學入門(卷二) 李천
  33. 古今醫鑑 龔信
  34. 增補萬病回春 龔廷賢
  35. 醫宗必讀 李中梓
  36. 備急千急要方(卷四十) 遜思邈
  37. 東醫神經精神科學會誌 v.8 no.2 Alzheimer型 痴呆患者 2例에 對한 臨床的 考察 金保冏(外)
  38. 惠和醫學 v.7 no.1 痴呆患者 17例에 對한 臨床的 考察 鄭仁哲(外)
  39. 中醫雜誌 v.38 no.10 謝海洲治療腦萎縮經驗 郭字鵬(外)
  40. 上海中醫藥雜誌 v.3 呆從痰治 張覺人
  41. 동의신경과학회지 v.7 no.1 痴呆에 對한 文獻的 考察 鄭仁哲;李相龍
  42. 新中醫 編輯部 v.29 no.5 補腎活血化痰法治療老年性痴呆 32例 徐恒旺
  43. MERIDIAN v.6 no.1 Essential Oil흡입에 대한 EAV측정치의 변화 연구-Aromatherapy의 임상적용을 위한 예비연구 오홍근
  44. Biochem. Biophys. Res. Commun. v.241 John, D.R.;Kaushik, D.;James, P.K.
  45. FEBS Lett. v.324 Dubois, M.F.;Bensaude, O.
  46. J. Biol. Chem. v.272 Lin, R.Z.;Hu, Z.W.;Chin, J.H.;Hoffman, B.B.
  47. Science v.267 Thompson, C.B.
  48. Cell v.75 Yuan, J.;Shaham, S.;Ledoux, S.;Ellis, H.M.;Horvitz, H.R.
  49. Cell v.75 Miura, M.;Zhu, H.;Rotello, R.;Hartweig, E.A.;Yuan, J.
  50. J. Biol. Chem. v.269 Fernandes, A.T.;Litwack, G.;Alnemri, E.S.
  51. Genes Dev. v.8 Kumar, S.;Kinoshita, M.;Noda, M.;Copeland, N.G.;Jenkins, N.A.
  52. EMBO J. v.14 Faucheu, C.;Diu, A.;Chan, A.;Blanchet, A.M.;Miossec, C.;Herve, F.;Collarddutilleul, V.;Gu, Y.;Aldape, R.A.;Lippke, J.A.;Rocher, C.;Su, M.;Livingston, D.J.;Hercend, T.;Lalanne, J.L.
  53. Cancer Res. v.55 Ferandes-Alnemri, T.;Litwack, G.;Alnemri, E.S.
  54. J. Biol. Chem. v.270 Munday, N.;Vaillancourt, J.P.;Ali, A.;Casano, F.J.;Miller, D.K.;Molineaux, S.M.;Yamin, T.T.;Yu, V.L.;Nicholson, D.W.
  55. Nature v.376 Nicholson, D.W.;Ali, A.;Thornberry, N.A.;Vaillancourt, J.P.;Din, C.K.;Gallant, M.;Gareau, Y.;Griffin, P.R.;Labelle, M.;Lazebnik, Y.A.;Munday, N.A.;Raju, S.M.;Smulson, M.E.;Yamin, T.T.;Yu, V.L.;Miller, D.K.
  56. J. Cell Biol. v.123 Lazebnik, Y.A.;Cole, S.;Cooke, C.A., Nelson, W.G.;Earnshaw, W.C.
  57. Nature (London) v.371 Lazebnik, Y.A.;Kaufmann, S.H.;Denoyers, S.;Poirier, G.G.;Earnshaw, W.C.