동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제10권1호
  • /
  • Pages.95-108
  • /
  • 1999
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

원지(遠志)에 의한 뇌(腦) 성장세포(星狀細胞)로부터 염증성(炎症性) 세포활성물질(細胞活性物質) 분필(分泌)의 억제(抑制) 효과(效果)에 관(關)한 연구(硏究)

Studies on Inhibitory Effect of Inflammatory Cytokines Secretion from Brain Astrocytes by Polygala Tenuifolia

  • 황시영 (원광대학교 한의과대학 신경정신과 교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과 교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과 교실)
  • Hwang Si-Young (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Gang Hyeong-Won (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lyu Yeong-Su (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University)
  • 발행 : 1999.08.30
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초록

We investigated whether an aqueous extract of Polygala tenuifolia root (PTAE) inhibits secretion of inflammatory cytokines from primary cultures of mouse astrocytes. PTAE dose-dependently inhibited the Tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate $TNF-{\alpha}$ secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of $TNF-{\alpha}$ secretion from primary astrocytes by PTAE. Treatment of PTAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion to the level observed with LPS alone. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic cooperative effect of LPS and SP. Reverse transcriptase-polymerase chain reaction analysis demonstrated the significantly reduced level of the $TNF-{\alpha}$ mRNA was expressed in astrocytes treated with PTAE. These results suggest that PTAE has an antiinflammatory activity on the central nervous system curing some pathological disease states.

키워드

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