The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지

Otitis Media is one of the Most Common Disease of Otolaryngology and Pediatrics

소아(小兒) 재발성삼출성(再發性渗出性) 중이염(中耳炎)에 가미형개연교탕(加味荊芥連翹湯)이 중이강삼출액내(中耳腔渗出液內) 세포활성물질(細胞活性物質)에 미치는 영향(影響)

  • Lee Eun-Mi (Dept. of pediatrics, College of Oriental Medicine Wonkwang University) ;
  • Park Eun-Jung (Dept. of pediatrics, College of Oriental Medicine Wonkwang University)
  • 이은미 (원광대학교 소아과학 교실) ;
  • 박은정 (원광대학교 한의과대학)
  • Published : 1999.12.15
Download PDF
⟨ Previous Next ⟩

Abstract

The author measured IL-2, IL-4, IL-6, TNF-${\alpha}$ and total protein(TP) level of middle ear effusion(MEE) of 24 ears - 13 ears of them had treated by antibiotics, 11 of them by Kami-hyunggyeyungyotang - of pediatric recurrent otitis media with effusion(PROME) using ELISA assay, and compared the level of cytokines(pg/ml)/TP(mg/dl). And investigated the clinical finding in those children. The results were obtained as follows: 1. The level of IL-2／TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P〈0.05). 2. The level of IL-4/TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P〈0.0l). 3. The level of IL-6/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P〈0.05). 4. The level of TNF-${\alpha}$/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P〈0.01) 5. 79.1% of children with recurrent otitis media with effusion(ROME) were also complicated to chronic sinusitis. The children's t-test was used to make a statistical comparison between the groups. According to above results, Kami-hyunggyeyungyotang is considered to be used for treatment 'recurrent otitis media with effusion' by control produce of cytokines which are connected with inflammatory reaction.

Keywords

References

  1. 소아과진료 홍창의
  2. 中醫小兒科學 王伯岳;江育仁
  3. 만성 삼출성 중이염에 영향을 미치는 Cytokinine의 역할 김도일
  4. 한이인지 v.29 no.6 삼출성 중이염에서 면역방사계추측정법을 이용한 IL-6의 역할 여상원(외)
  5. 대한한방소아과학회지 v.11 no.1 荊芥漣翹湯과 加味荊芥漣翹湯이 消炎${\cdot}$鎭痛 및 抗알레르기에 미치는 영향 박은정
  6. 中醫兒科學 王伯岳
  7. 대구 서구지역 어린이집 아동들의 삼출성 중이염의 유병율 이경철
  8. 취학전 아동에서 삼출성 중이염의 경과 및 빈도에 관한 고찰 유문식
  9. 소아과학 홍창의
  10. 免疫學 하대유
  11. 耳鼻咽喉科學[頭頸部外科] 盧寬澤
  12. Logan tunner's disease of the nose, throat and ear Birrel, J.F.
  13. 諸病源候論校釋 隨${\cdot}$巢元方
  14. 備急千金要方 唐${\cdot}$孫思邈
  15. 外臺秋要(下) 교육주보사출판부(編)
  16. 幼幼新書 宋${\cdot}$劉昉撰
  17. 三因極一病證方論 宋${cdot}$陳無擇
  18. 衛生寶鑑 元${\cdot}羅天益
  19. 活幼口議 元${\cdot}$會世榮
  20. 編註 醫學入門 明${\cdot}$李정
  21. 醫學綱目 明${\cdot}$樓英
  22. 證治維繩(五) 幼科 明${\cdot}$王肯堂
  23. 景岳全書 上 明${\cdot}$張介寶
  24. 幼科折衷 明${\cdot}$泰昌遇
  25. 古今醫鑑 明${\cdot}$공信
  26. 東醫寶鑑 조선${\cdot}$許浚
  27. 국역 醫學心悟 淸${\cdot}$程國彭
  28. 濟衆新編 淸${\cdot}$康明吉
  29. 及幼方 趙廷俊
  30. 醫宗損益 上 黃度淵
  31. 東醫治療經驗集成-第17券 耳鼻咽喉科${\cdot}$口腔科疾病 v.17 薛姬子
  32. 萬病醫藥顧問 第 8種 耳鼻咽侯科 陸靑節
  33. 兒科證治 曺旭(編)
  34. 片玉心書 明${\cdot}$萬全;劉忠德(篇);劉鵬拳(篇);薛鳳奎(等)(篇)
  35. 赤水玄珠 明${\cdot}$孫一奎
  36. 醫貫 明${\cdot}$趙獻可
  37. 奇效良方 明${\cdot}$方賢
  38. 實用中西醫結合診斷治療學 陳貫廷(外)
  39. 小兒集方 유준기;전찬일
  40. 仁濟直指 外西種 宋${\cdot}$楊士瀛
  41. 聖濟總錄(下冊) 宋${\cdot}$趙佶
  42. 丹溪心法(丹溪醫集中) 元${\cdot}$朱震亨
  43. 證治彙輔 淸${\cdot}$李用梓
  44. 醫? 淸${\cdot}$何夢?
  45. 濟生方(文淵閣四庫全書) v.11 宋${\cdot}$嚴用和
  46. 保赤存眞 淸${\cdot}$余夢墉;劉忠德(篇);劉鵬拳(篇);薛鳳奎(等)(編)
  47. 黃帝內經素問今釋 王埼(外)
  48. 靈樞經校釋 河北醫學院
  49. 鍼灸甲乙經校釋 山東中醫學院
  50. 外科正宗 明${\cdot}$陳實功
  51. 辨證奇聞 淸${\cdot}$錢松
  52. 幼幼集成 淸${\cdot}$陳復正(譯)
  53. 醫門實鑑 周命新
  54. 珍神經驗神方 李?宰
  55. 幼幼集 明${\cdot}$孟繼孔;劉忠德(編);劉鵬拳(編);薛鳳奎(等)(編)
  56. 中西醫診療方法叢書 兒科分冊 楊錫强(等)(編)
  57. 古今醫統大全(下冊) 明${\cdot}$徐春甫
  58. 臨床本草學 辛民敎
  59. 天津中醫 v.13 中西醫結合治療急性分沁性中耳炎 86에 療效觀察 袁德玲
  60. 新中醫 v.28 淺談變症 與辨病相結合治療小兒非化膿性中耳炎 廖月紅
  61. 四川中醫 v.15 複方黃連治療中耳炎100例 王旭輝
  62. 醫方考 明${\cdot}$吳崑
  63. 校正增補 萬病回春 明${\cdot}$공廷賢
  64. Essential otolaryngology Lee, K.J.
  65. Nipp.on Jibiinkika Gakkai Kaihc. v.101 no.9 The role of IL-1 beta in murine model of otitis media with effusion Kurono, Y.;Hirono, T.;Watanabe, T.;Suzuki, M.;Mogi, G.
  66. Pediatr Res v.24 The interleukins Strober, W.;James, S.P.
  67. Immunol Rev v.51 Interleukin 2 : A class of T cell growth factors Mochizuki, Watson J.
  68. Annu Rev Immunol v.7 Th1 and Th2 cells : different pattern of lymphokine secretion lead to different functional properites Mosmann, T.R.;Coffman, R.L.
  69. Nature v.339 Mast cell clones produce lymphokines in response to cross-linkage of Fc ${\varepsilon}$ RI or to calcium ionophore Plaut, M.;Pierce, J.H.;Watson, C.J.(et al.)
  70. J Immunol v.148 CD8-T cells can be primed in vitro to produce IL-4 Seder, R.A.;Boulay, J.L.;Finkelman, F.(et al.)
  71. Science v.254 Defining protective responses to pathogens : 세포활성물질 profiles in leprosy leisons Yamamura, M.;Uyemura, K.;Deanse, R.J.(et al.)
  72. Arch Otolaryngol Head Neck Surg v.118 no.7 Demonstration of interleukin 6 in middle ear effusion Yellon, R.F.;Leonardo, G.;Marucha, P.(et al.)
  73. Ann Otol Thinol Laryngol v.107 no.1 Relationship of endotoxin to tumor necrosis factor-alpha and interleukin-1 beta in children with ottis media with effusion Willett, D.N.;Rezaee, R.P.;Billy, J.M.;Tighe, M.B.;DeMaria, T.F.
  74. The chmokine Factsbook Vaddi, K.;Keller, M.;Newton, R.C.
  75. Clin. Exp. Allergy v.26 no.9 The chemokines : Their potential role in allergic inflammation Teran, L.M.;Davies, D.E.
  76. Recent advances in otitis media Respiratory syncytial virus infection of the middle ear : The role of cytokines, cell adhesion molecules and virus antigen in otitis media Okamoto, Y.;Sarashina, N.;Matsuzaki, Z.(et al.);Mogi G.
  77. Ann otol Rhinol Layngol v.107 Th1/Th2 cytokine profiles the nasopharyngeal lymphoid tissues of children with recurrent otitis media Bernstein, J.M.
  78. Arch Otolaryngol Head Neck Surg v.118 no.7 Demonstration of interleukin 6 in middle ear effusions Yellon, R.F.
  79. Science v.257 An eosinophil dependent9 mechanism for the antitumor effect of interleukin-4 Tepp.er, R.I.;Coffman, R.L.;Leder, P.
  80. J Immunol v.149 no.1 IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis Zubiaga, A.M.
  81. Proc Natl Ascd USA v.93 no.8 Comparative interleukin (IL-2)/ interferon INF-gamma and IL-4/IL-10 response during acute infection of macaques inoculated nef-truncated or pathogenic SCImac251 virus Benveniste, O.