성향정기산(星香正氣散)이 가토(家兎)의 경동맥(頸動脈) 평골근(平滑筋) 절편(切片)에서 t-Butyl Hydroperoxide 에 의한 지질과산화(脂質過酸化) 및 수축(收縮)에 미치는 영향(影響)

Effect of Sunghyangchungi-san (Xingxiangzhengqi-san) on Contraction and Lipid Peroxidation Induced by t-Butyl Hydroperoxide in Isolated Rabbit Carotid Artery

  • 김영균 (동의대학교 한의학과 내과학교실) ;
  • 김종훈 (동의대학교 한의학과 내과학교실)
  • 발행 : 1999.09.30

초록

This study was undertaken to evaluate the effect of Sunghyangchungi-san (SHCS) on the oxidant-induced contraction and lipid peroxidation in rabbit carotid artery. Vascular rings isolated from rabbit carotid artery were exposed to t-butyl hydroperoxide (t-BHP), an extrinsic oxidant, and the effect of SHCS on the changes of vascular tension and lipid peroxidation induced by t-BHP was determined. t- BHP induced a slowly developing and sustained contraction of the arterial rings. SHCS effectively relaxed the arterial rings that were pre-contracted by t-BHP. The responses to SHCS were partially dose-dependent at concentrations lower than 0.5 mg/ml. When SHCS was applied prior to the exposure to t-BHP, it inhibited the t-BHP-induced contraction as well. t- BHP increased lipid peroxidation in a dose-dependent manner. SHCS as well as well-known anti-oxidants GSH and DPPD reduced significantly lipid peroxidation induced by t-BHP. SHCS partially blocked the increase in $^{45}Ca$ uptake induced by t-BHP. In contrast to SHCS, anti-oxidants GSH and DPPD failed to inhibit significantly the t- BHP-induced contraction or $^{45}Ca$ uptake. From the above results, it is suggested that SHCS relaxed t-BHP-induced contraction of rabbit carotid artery independently of its anti-oxidant action, and inhibition of $Ca^{2+}$ influx may contribute to the underlying mechanism.

키워드

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