대한한의학회지 (The Journal of Korean Medicine)

  • 제20권1호
  • /
  • Pages.113-121
  • /
  • 1999
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

갈화해정탕이 주상(酒傷)에 미치는 영향 - ethanol-유도 위점막의 산화적 손상을 중심으로 -

GalhuaHaeJungTang Inhibit Ethanol-induced Gastric Injury in Rats

  • 채종구 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실)
  • Chae, Jong-Koo (Dept. of Physiology, College of Oriental Medicine, Dong Guk University) ;
  • Shin, Heung-Mook (Dept. of Physiology, College of Oriental Medicine, Dong Guk University) ;
  • Kim, Gil-Whon (Dept. of Physiology, College of Oriental Medicine, Dong Guk University)
  • 발행 : 1999.03.30
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초록

This Study was carried out to investigate the protective effect of GalHwaHaJungTang(GHT) on the gastric lesions indused by ethanol in rats. Rats were pretreated with GHT extract 1.7ml/kg, 3.4ml/kg, 5ml/kg and then were given orally 1ml of absolute ethanol 30min later. The animals were killed 1hr after ethanol treatment In morphorogic change, ethanol induced prominent longitudinal hemorrhagic lesions in the stomach. But GHT-pretreatment showed a dose-depentent decrease in the mucosa lesions. GHT extract siginificantly reduced lipid peroxidation and also induced an increase of superoxide dismutase(SOD), catalase and gluthathion(GSH) levels, but showed no influence in the type conversion of xanthine oxidase. These results suggest that the proposed gastroprotective effect may involve activation of antioxidant effects, but independent of the xanthine oxidase system.

키워드

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