숙지황(熟地黃) 제조 방법에 따른 성분변화에 관한 연구

Changes in the Constituents of Rehmanniae Radix during Processing

  • 홍양표 (경원대학교 한의과대학 본초학교실) ;
  • 김윤상 (경원대학교 한의과대학 본초학교실) ;
  • 손영종 (경원대학교 한의과대학 한의학연구소) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Hong, Yang-Phyo (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Yun-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Son, Young-Jong (Institute of Oriental Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 발행 : 1999.03.30

초록

In order to analyze the changes in the contents of Rehmanniae Radix during processing, the constituents of Rehmanniae Radix Preparata, such as catalpol, 5-HMF and the carbohydrates, were analyzed, The results were: 1. The catalpoI contents of Rehmanniae Radix Preparata remarkably decreased during the 1-4th steps in the processing, and the concentrations of 5-9th Rehmanniae Radix Preparatas were very low. 2. The contents of 5-HMF increased gradually with each additional processing. and the increasing rate in oven-dried Rehmanniae Radix Preparata was greater by about 2-folds than that of sun-dried. 3. Rehmanniae Radix contained a lot of sugars. such as rhamnose, raffinose and stachyose. In the course of the process for sun-dried or oven-dried Rehmanniae Radix Preparata., rhamnose disappeared during the 1-2nd step, but raffinose and stachyose stayed the same. 4. The level of fructose, developed at the first processing step, stayed the same during each additional processing for sun-dried Rehmanniae Radix Preparata. But, the level gradually decreased after the 6th processing step for oven-dried Rehmanniae Radix Preparata.

키워드

참고문헌

  1. 本草三家合註 v.卷一 張隱菴;葉天士;陳修園(編)
  2. 新編中醫藥大辭典 v.下 新文豊出版公司(編)
  3. 本草求眞 黃官繡(纂)
  4. Yakugaku Zasshi v.116 no.2 Studies on Rehmanniae radix. III. The relation between changes of constituents and I mprovable effects on hemorheololgy with the processing of roots of Rehmannia glutinosa. Kubo, M.;Asao, T.;Matsuda, H.;Yutani, S.;Honda, S.
  5. Yakugaku Zasshi v.115 no.12 Chemical studies on crude drug processing. X. On the constituents of rehmanniae radix (1):comparison of the constituents of various rehmanniae radixes originating in China, Korea, and Japan. Kitagawa, I.;Fikuda, Y.;Taniyama, T.;Yoshikawa, M.
  6. Chung Kuo Chung Yao Tsa Chih. v.16 no.6 Analysis and comparison of acidic constituents in petroleum ether soluble fraction of radix Rehmanniae and its processed products. Bian, B.;Ni, M.;Wang, H.
  7. Chung Kuo Chung Yao Tsa Chih. v.20 no.8 Determination of total saccharide and several main saccharides in Rehmannia glutinosa Libosh, and its processed products. Bian, B;Wang, H.;Ni, M.
  8. Chung Yao Tung Pao. Jan. v.9 no.1 Comparison of monosaccharide contents between the raw and prepared roots of Rehmannia. Liu, Z.Y.
  9. Chung Kuo Chung Yao Tsa Chih. v.14 no.3 Analysis and comparison of free amino acids in Rehmannia glutinosa Libosch, and its products. Ni, M.Y.;Bian, B.L.;Jiang, L.
  10. 1996년도 생약,한약제 품질 표준화 연구 서울대학교천연물과학연구소
  11. 상용생약의 정량분석 원도희(외7인)
  12. J. Chromatogr. A v.782 no.2 Analysis of ethereal extracts of wines and other alcoholic beverages by high-performance liquid chromatography with microbore columns. Cartoni, G.P.;Coccioli, F.;Spagnoli, M.
  13. J. Chromatogr. Sci. v.35 no.12 High-performance liquid chromatographic determination of 2-furaldehyde and 5-hydroxy-methyl-2-furaldehyde in fruit juices. Lo Coco, F.;Novelli, V.;Valentini, C.;Ceccon, L.
  14. J. Chromatogr. A v.730 no.1-2 Rapid reversed-phase liquid chromatographic determination of patulin in apple juice. Gokmen, V.;Acar, J.
  15. J Assoc Off Anal Chem v.63 no.1 Hydroxymethylfurfural and honey adulteration White, J.W. Jr.;Siciliano, J.
  16. Vopr. Potan.6 1987. Formation of hydroxy methylfurfural during the storage and processing of food products. Chepurnoi, I.P.;Kunixhev, S.M.;Chebotareva, N.G.
  17. J. Clin. Pharm. Ther. v.18 no.1 Detection and determination of interfering 5-hydroxymeth-ylfurfural in the analysis of caramel-coloured pharmaceutical syrups. Hewala, I.I.;Blaih, S.M.;Zoweil, A.M.;Onsi, S.M.
  18. Carbohydr. res. v.199 no.1 Mechanism of formation of 5-(hydroxymethyl)-2-furaldehyde from D-fructose an sucrose. Antal, M.J. Jr.;Mok, W.S.;Richards, G.N.
  19. J. Assoc. Off. Anal. Chem. v.63 no.5 Rapid HPLC determination of hydroxy methylfurfural in tomato paste. Allen, B.H.;Chin, H.B.
  20. Hum Exp Toxicol v.9 no.1 Influence of 5-hydroxymethylfurfural(5-HMF) on the overall metabolism of human blood cells. Nassberger, L.
  21. J. Chromatogr. v.467 no.2 Reversed phase high performance liquid chromatographic method for the quantification of 5-hydroxy-methylfurfural as the major degradation product of glucose in infusion fluids. Cook, A.P.;Macleod, T.M.;Appleton, J.D.;Fell, A.F.
  22. Clin. Chim. Acta v.47 The presence of furan derivatives in patients receiving fructose-containing solution intravenously. Jellum, E.;B${\o}$rresen, H.C.;Eldjarn, L.
  23. J. Toxicol. Environ. Health v.22 no.1 Rapid and complete urinary elimination of [14C]-5-hydroxy methyl-2-2furaldehyde administered orally or intravenously to rats. Germond, J.E.;Philippossian, G.;Richli, U.;Bracco, L.;Arnaud, M.J.
  24. Fundam. Appl. Toxicol. v.4 no.5 A review of 5-hydroxymethylfurfural(HMF) in parenteral solutions. Ulbricht, R.J.;Northup, S.J.;Thomas, J.A.
  25. Perit. Dial. Int. v.15 no.8 Are aldehydes in heat-sterilized peritoneal dialysis fluids toxic in vitro? Wieslander, A.P.;Andren, A.H.;Nilsson-Thorell, C.;Muscalu, N.;Kjellstrand, P.T.;Rippe, B.