Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Volume 25 Issue 4
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- Pages.304-310
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- 1999
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- 2234-7550(pISSN)
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- 2234-5930(eISSN)
ANALYSIS OF MINOCYCLINE IN TISSUE AND SERUM AFTER LOCAL APPLICATION OF MINOCYCLINE OINTMENT (by High-Performance Liquid Chromatography)
미노싸이클린 연고의 근육 내 투여 후 조직 및 혈중 약물농도의 분석 (High-Performance Liquid Chromatography를 이용하여)
- Hwang, Hye-Wook (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University) ;
- Lee, Sang-Chull (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University) ;
- Kim, Sung-Jin (Dept of Dental Pharmachology, College of Dentistry, Kyung Hee University)
- Published : 1999.12.31
Abstract
This study was designed to find the effect of Minocycline loaded microcapsule applied locally to tissue by measuring drug concentration in tissue and serum by HPLC and to achieve optimal drug delivery system and duration to a specific target site. Control group were administrated minocycline intramuscularly twice a day with
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