Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Effect of Ionic Enhancers in the Iontophoresis of Lidocaine

리도케인의 이온토포레시스에 있어서 이온 피부투과증진제의 영향

  • Kim, Jae-Hong (Department of Chemical Engineering, Chungnam National University) ;
  • Shin, Byung-Chul (Biomaterials Division, Korea Research Institute of Chemical Technology) ;
  • Choi, Ho-Suk (Department of Chemical Engineering, Chungnam National University) ;
  • Kim, Sung-Soo (Biomaterials Division, Korea Research Institute of Chemical Technology) ;
  • Park, Young-Do (Central Research Institute, Dong Shin Pharm. Co., Ltd.)
  • 김재홍 (충남대학교 화학공학과) ;
  • 신병철 (한국화학연구소 화학소재연구단 2팀) ;
  • 최호석 (충남대학교 화학공학과) ;
  • 김승수 (한국화학연구소 화학소재연구단 2팀) ;
  • 박영도 (동신제약 (주) 중앙연구소)
  • Published : 1999.09.20
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Abstract

Lidocaine(2-Diethylaminoaceto-2', 6'-xylidide) was transdennally delivered by iontophoresis and the effect of enhancer on the delivery of lidocaine was studied. We delivered lidocaine through the skin of hairless mouse using diffusion cell and investigated the effect of the amount of cation salts such as sodium chloride, calcium acetate, zinc acetate and aluminum acetate on the drug delivery. The amounts of transported drugs and adsorbed metal ions were measured by HPLC(High Perfonnance Liquid Chromatography) and AAS(Atomic Absorption Spectrophotometry), respectively. The addition of zinc acetate and aluminum acetate greatly enhanced the delivery of lidocaine. The detection of two metal ions by AAS seemed to support the idea that the astringency effect of these ions were the main reason for the enhancement of transdermal delivery.

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