Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 31 Issue 1
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- Pages.246-251
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- 1999
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- 0367-6293(pISSN)
Mutagenic Mechanism of Chloropropanols in Escherichia coli
대장균 변이주를 이용한 Chloropropanol 변이원성 기구의 해석
- Song, Geun-Seoup (Department of Food Engineering, Iri National College of Agriculture and Technology) ;
- Han, Sang-Bae (Seoul FDA) ;
- Choi, Dong-Seong (Division of Biotechnology and Environmental Engineering, Woosuk University)
- Published : 1999.02.28
Abstract
This study was designed to evaluate the mutagenicity and the primary mutagenic mechanism of chloropropanols by using various genotypes of E. coli WP2, E. coli TK and E. coli GW series strains. Chloropropanols showed the low mutagenic activities in E. coli WP2s and WP2 establishing the following order; 2,3-DCP> 3-MCPD>1,3-DCP. As compared with E. coli WP2s, the decrease of mutagenic activity and the increase of survival rate in E. coli WP2
다양한 유전형질을 갖고 있는 E. coli WP series, E. coli TK series 및 E. coli GW series 변이주들을 이용하여 chloropropanol의 변이원성 기구를 해석하였다. 3종류의 chloropropanol 모두 E. coli WP2s와 WP67에서는 돌연변이활성이 나타났으나 E. coli WP2와 CM611에서는 변이원성이 거의 나타나지 않았으며 2,3-DCP>3-MCPD>1,3-DCP 순으로 돌연변이 활성을 나타내었다. E. coli WP2s와 비교하여 E. coli WP2