Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Studies on the Cytotoxicity of Sophora flavescens Ait. Extract Against L1210 and $P388D_1$ Cells (II)

L1210 및 $P388D_1$에 대한 고삼 추출물의 세포독성에 관한 연구(II)

  • Cho, Hoon (Kuhnil Pharmaceutical Co., LTD.) ;
  • Yang, Eun-Yeong (Kuhnil Pharmaceutical Co., LTD.) ;
  • Kim, Jong-Soo (Department of Chemical Engineering, Iksan National College) ;
  • Yoo, Il-Soo (Department of Chemical Engineering, Iksan National College) ;
  • Ryu, Do-Gon (Department of Physiology, School of Oriental Medicine, Wonkwang University) ;
  • Kang, Kil-Ung (Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jeong-Ho (Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 조훈 (건일제약(주)) ;
  • 양은영 (건일제약(주)) ;
  • 김종수 (익산대학 화학공업과) ;
  • 유일수 (익산대학 화학공업과) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 강길웅 (한의학전문대학원 천연물학교실) ;
  • 이정호 (한의학전문대학원 천연물학교실) ;
  • 백승화 (한의학전문대학원 천연물학교실)
  • Published : 1999.12.30
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Abstract

This study was carried out to evaluate cytotoxicity of the extracts from Sophora flavescens Ait. against L1210 (lymphocytic leukemia) and $P388D_1$ (lymphoid neoplasms) cells in vitro. We have determined cytotoxicity by MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazo-liumbromide} assay. The order of cytotoxicity of Sophora flavescens Ait. extracts against L1210 and $P388D_1$ cells in vitro is as follows: AM> EASF > CFSF > MTSF > WSF > HXSF and AM> EASF> CFSF> MTSF> HXSF> WSF. These results suggest that the ethyl acetate soluble extract of Sophora flavescens Ait may be a valuable choice for the development of antitumor agents.

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