Metabolism of Glycyrrhizin in Polyprescriptions Containing Glycyrrhizae Radix by Human Intestinal Bacteria and Their Inhibitory Effects on Some Enzymes

감초 함유 처방의 글리치리진 대사와 몇가지 효소저해효과

  • Kim, Nam-Jae (East-West Medical Research Institute, Kyunghee University) ;
  • Bae, Eun-Ah (Department of Food and Nutrition Kyunghee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition Kyunghee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyunghee University)
  • 김남재 (경희대학교 동서의학연구소) ;
  • 배은아 (경희대학교 식품영양학과) ;
  • 한명주 (경희대학교 식품영양학과) ;
  • 김동현 (경희대학교 약학대학 약학과)
  • Published : 1999.09.30

Abstract

To analyze scientifically the prescription principle of polyprescriptions (Gamchotang, Daewhanggamchotang, Jakyakgamchotang, Gamchogungangtang and Gilkyungtang) containing Glycyrrhizae Radix, the transforming rate of glycyrrhizin in these polyprescriptions to 18 ${\beta}-glycyrrhetinic$ acid and their inhibitory effect on ${\beta}-glucuronidase$, hyaluronidase, phosphodiesterase and trypsin were investigated. When Glycyrrhizae Radix containing polyprescriptions were extracted with water, the contents of glycyrrhizin in water extract of Glycyrrhizae Radix with Rhei Rhizoma or with Zingiberis Rhizoma were higher than that of Glycyrrhizae Radix only, but that in water extract of Glycyrrhizae Radix with Platicodi Radix was lower than that of Glycyrrhizae Radix only. By human intestinal bacteria, glycyrrhizin was metabolized to 18 ${\beta}-glycyrrhetinic$ acid. These metabolism of glycyrrhizin in polyprescriptions containing Glycyrrhizae Radix was inhibited by Rhei Rhizoma, Paeoniae Radix and Platicodi Radix, but was not affected by Zingiberis Rhizoma. The inhibitory activity of Glycyrrhizae Radix on hyaluronidase and ${\beta}-glucuronidase$, was synergistic with Rhei Rhizoma or Zingiberis Rhizoma, but was antagonistic by Platicodi Radix.

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