Korean Journal of Pharmacognosy (생약학회지)
- Volume 30 Issue 3
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- Pages.244-249
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Antiviral Effect of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons on Vesicular Stomatitis Virus (Indiana Serotype)
잔나비걸상 수용성 물질의 Vesicular Stomatitis Virus (Indiana Serotype)에 대한 항바이러스작용과 Interferon과의 병용효과
- Kim, Young-So (College of Pharmacy, Chungbuk National University) ;
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Eo, Seong-Kug
(College of Pharmacy, Chungbuk National University) ;
- Han, Seong-Sun (College of Pharmacy, Chungbuk National University)
- Published : 1999.09.30
Abstract
In order to find less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata(Pers.) Karst. Antiviral activity of EA against vesicular stomatitis virus [Indiana serotype, VSV(IND)] was examined in Vero cells using plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha or gamma were examined on the multiplication of VSV(IND). EA caused a concentration-dependent reduction in the plaque formation of VSV(IND) with 50% effective concentration
Keywords
- Combination index (CI);
- Elfvingia applanata;
- plaque reduction assay;
- vesicular stomatitis virus [Indiana serotype, VSV(IND)]