Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibition Activities of Sea Weeds on Prolyl Endopeptidase, Tyrosinase and Coagulation

해조류 메탄올 추출물의 Prolyl Endopeptidase, Tyrosinase 저해 및 항응고 활성 스크리닝

  • Lee, Hyun-Jin (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Kim, Jin-Hui (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Lee, Chu-Hyun (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Kim, Jong-Sik (Department of Chemistry, Konyang University) ;
  • Kwak, Sang-Tae (Department of Biochemistry, College of Medicine, Konyang University) ;
  • Lee, Kyung-Bok (Department of Biochemistry, College of Medicine, Konyang University) ;
  • Song, Kyung-Sik (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Choi, Byung-Wook (Department of Chemical Technology, Taejon National University) ;
  • Lee, Bong-Ho (Department of Chemical Technology, Taejon National University)
  • 이현진 (경북대학교 농화학과) ;
  • 김진희 (경북대학교 농화학과) ;
  • 이주현 (경북대학교 농화학과) ;
  • 김종식 (건양대학교 화학과) ;
  • 곽상태 (건양대학교 의과대학 생화학교실) ;
  • 이경복 (건양대학교 의과대학 생화학교실) ;
  • 송경식 (경북대학교 농화학과) ;
  • 최병욱 (대전산업대학교 공업화학과) ;
  • 이봉호 (대전산업대학교 공업화학과)
  • Published : 1999.09.30
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Abstract

About forty sea weeds were screened for their inhibitory effects against prolyl endopeptidase, tyrosinase and thrombus coagulation. Out of them, methanolic extract of Ecklonia cava, Sargassum patens, Sargassum hemiphyllum, Sargassum thunbergii, Sargassum singgildianum, Hizikia fusiformis, and Ishige okamurae inhibited more than 90% of prolyl endopeptidase activity at 40 ppm. Sargassum siliquastrum and Ecklonia cava exhibited 51% and 76% of inhibitory activity against tyrosinase at 40 ppm, respectively. In APTT assay system, Sargassum singgildianum, Pterocladia capilacea and Hizikia fusiformis delayed coagulation of thrombus about two times (210, 211, and 198% over control at ca 367 ppm, respectively) and in TT assay, Lomentaria catenata, Laurencia okamurae, and Hizikia fusiformis did most effectively (216,197, and 251% at ca 367 ppm, respectively).

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