생약학회지 (Korean Journal of Pharmacognosy)
- 제30권2호
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- Pages.226-230
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
고혈압 흰쥐에서 Cumambrin A의 혈압 강하 효과
Effect of Cumambrin A Treatment on Blood Pressure in Spontaneously Hypertensive Rats
- Hong, Yong-Geun (Department of Biochemistry and Cardiovascular Research Institute, Gyeongsang National University) ;
- Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University) ;
- Pak, Yun-Bae (Department of Biochemistry and Cardiovascular Research Institute, Gyeongsang National University)
- 발행 : 1999.06.30
초록
We have isolated a sesquiterpene lactone, cumambrin A from the dried flowers of Chrysanthemum boreale Makino and reported its chemical structure. The aim of the present study was to investigate whether the exogenous administration of cumambrin A has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In vitro studies: Relaxative response induced by cumainbrin A was increased with dose-dependent manner and showed maximizing response at a concentration of
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