Korean Journal of Pharmacognosy (생약학회지)
- Volume 30 Issue 2
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- Pages.137-144
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Isolation of Torilin from Torilis japonica Fruit and Its Analgesic and Anti-inflammatory Activities
사상자 중 Torilin의 분리 및 진통소염작용
- Cho, Sung-Ig (Natural Products Research Institute, Seoul National University) ;
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Kang, Sam-Sik
(Natural Products Research Institute, Seoul National University) ;
- Kim, Kyung-Ran (College of Pharmacy, Sookmyung Women's University) ;
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Kim, Tae-Hee
(College of Pharmacy, Sookmyung Women's University) ;
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Lee, Eun-Bang
(Natural Products Research Institute, Seoul National University)
- 조성익 (서울대학교 천연물과학연구소) ;
-
강삼식
(서울대학교 천연물과학연구소) ;
- 김경란 (숙명여자대학교 약학대학) ;
-
김태희
(숙명여자대학교 약학대학) ;
-
이은방
(서울대학교 천연물과학연구소)
- Published : 1999.06.30
Abstract
Torilin was isolated from haxane fraction of Torilis Fructus extract. Torilin produced inhibition of the acetic acid-induced and phenylquinone-induced writhing syndrome at the oral doses of 30 and 90 mg/kg in mice. It also increased the pain threshold at the oral doses of 30, 90 and 270 mg/kg in the tail pressure method and the Randall-Selitto method. However, it did not show a hypothermic action at the oral doses of 30 and 90 mg/kg in mice. The compound exhibited strong anticarrageenan activity at the oral doses of 90 and 270 mg/kg in rats, and had inhibitory effect on the vascular permeability at the oral doses of 30 and 90 mg/kg in mice. It also showed potent inhibition of leucocyte emigration in CMC-pouch at the doses of 3 and 9 mg/rat, sc. The acute toxicity of torilin was very weak: the