Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Bupleuri Radix Aqua-Acupuncture Solution on Immune Response in Mice

시호 약침제제가 생쥐의 면역활성에 미치는 영향

  • Moon, Jin-Young (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Lim, Jong-Kook (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Choi, Hey-Kyung (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Lee, Yim-Tae (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Lee, Hang-Woo (College of Science, Yeungnam University) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University)
  • 문진영 (동국대학교 한의과대학 경혈학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실) ;
  • 최혜경 (동국대학교 한의과대학 경혈학교실) ;
  • 이임태 (동국대학교 의과대학 약리학교실) ;
  • 이항우 (영남대학교 이과대학 생물학과) ;
  • 남경수 (동국대학교 의과대학 약리학교실)
  • Published : 1999.06.30
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Abstract

In order to investigate the effects of Bupleuri Radix aqua-acupuncture solution (BRAS) on immuno suppression induced by glucocorticoid, ICR mice were administrated with glucocorticoid (80 mg/kg) for 7 days, and immunized with hapten, methamphetamine-horseradish peroxidase $(10\;{\mu}g/mouse)$. And then, BRAS (0.2ml/mouse) injected into $CV_4\;and\;BL_{23}$, which are the classical acupuncture points in traditional medicine, for 7 days. And then B and T cells proliferation and cytolytic activity of natural killer (NK) cells were measured. Intraperitoneal injection of glucocorticoid decreased lysozyme activity in macrophage and cytolytic activity of NK cell. B and T cell proliferation were significantly increased in aqua-acupuncture group compared to normal group. On the other hand, BRAS significantly increased the lysozyme activity in macrophage, and the cytolytic activity of purified NK cell on K562. These results suggest that BRAS at $CV_4\;and\;BL_{23}$ may proliferate B and T cells that are suppressed by glucocorticoid and activate NK cell activity.

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