Natural Product Sciences
- 제5권2호
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- Pages.88-92
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- 1999
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- 1226-3907(pISSN)
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- 2288-9027(eISSN)
Effects of Setaria italica on Gap Junction-Mediated Intercellular Communication for the Development of Cancer Chemopreventive Agents
- Son, Jang-Won (College of Veterinary Medicine, Seoul National University) ;
- Fang, Ming-Zhu (College of Veterinary Medicine, Seoul National University) ;
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Cho, Myung-Haing
(College of Veterinary Medicine, Seoul National University) ;
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Kim, Kyung-Ho
(College of Pharmacy, Kangwon National University) ;
- Kim, Soo-Un (Division of Applied Biology and Chemistry, College of Agriculture and Life Sciences, Seoul National University) ;
- An, Gil-Hwan (Department of Applied Biology, Sunmoon University) ;
- Lee, Chong-Soon (Department of Biochemistry, College of Natural Sciences, Yeungnam University) ;
- Kim, Ki-Nam (Natural Products Research Institute, Seoul National University) ;
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Chang, Il-Moo
(Natural Products Research Institute, Seoul National University) ;
- Mar, Woong-Chon (Natural Products Research Institute, Seoul National University)
- 발행 : 1999.06.01
초록
Inhibition of gap junction-mediated intercellular communication (GJIC) has been considered as an important factor in the tumor promotion phase of carcinogenesis. Recovery effects of natural products on gap junctional intercellular communication are measured by scrape-loading and dye transfer method using Lucifer yellow after administration of phorbol-12-myristate-13-acetate (PMA) on WBF344 cells. Among tested natural products, the hexane fraction and subfractions (F-01 and F-04) of Setaria italica were relatively effective for recovery of GJIC. The hexane fraction of Setaria italica