Natural Product Sciences
- 제5권2호
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- Pages.80-84
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- 1999
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- 1226-3907(pISSN)
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- 2288-9027(eISSN)
Flavonoids and chlorogenic acid from Eriobotrya japonica scavenge peroxynitrite
- Soung, Do-Yu (College of Pharmacy, Pusan National University) ;
- Kim, Jin-Sook (College of Pharmacy, Pusan National University) ;
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Chung, Hae-Young
(College of Pharmacy, Pusan National University) ;
- Jung, Hyun-Ah (Department of Food and Life Science, Pukyong National University) ;
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Park, Jong-Cheol
(Department of Oriental Medicine Resources, Sunchon National University) ;
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Choi, Jae-Sue
(Department of Food and Life Science, Pukyong National University)
- 발행 : 1999.06.01
초록
Peroxynitrite is a cytotoxic intermediate produced by the reaction between the superoxide anion radical and nitric oxide. Flavonoids (afzelin, quercitrin and quercetin 3-O-sambubioside), and chlorogenic acid and its methyl ester obtained from leaves of loquat (Eriobotrya japonica) have recently been shown to scavenge 1,1-diphenyl-2-picrylhydrazyl radical and to inhibit lipid peroxidation in mouse liver homogenate. The aim of this study is to investigate the inhibitory effects of the above components on peroxynitrite produced stimulated by 3-morpholinosydnonimine (SIN-1) to produce superoxide anion radical and nitric oxide at the same time. In addition, the present study tests whether or not the components directly scavenge peroxynitrite itself. The results showed that the components with the aromatic ortho-dihydroxyl groups (catechol) were more potent inhibitors of peroxynitrite formation by SIN-1. In particular, the methyl ester form of chlorogenic acid showed the most potent inhibition. At
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