Natural Product Sciences
- Volume 5 Issue 1
- /
- Pages.20-24
- /
- 1999
- /
- 1226-3907(pISSN)
- /
- 2288-9027(eISSN)
Anti-emetic Principles of Alpinia katsumadai Hayata
- Yang, Ye (Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University) ;
- Kinoshita, Kaoru (Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University) ;
- Koyama, Kiyotaka (Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University) ;
- Takahashi, Kunio (Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University) ;
- Tai, Takaaki (Kotaro Pharmaceutical Co. Ltd.) ;
- Nunoura, Yoshiki (Kotaro Pharmaceutical Co. Ltd.) ;
- Watanabe, Kazuo (Faculty of Pharmaceutical Sciences, Chiba University)
- Published : 1999.03.01
Abstract
Bioassay-guided fractionation of anti-emetic constituents of Alpinia katsumadai Hayata was performed. Nine compounds including one novel compound, (3R,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene (9) were isolated from it. Among these compounds, four diarylheptanoids, one sesquiterpenoid and one flavonoid showed anti-emetic activity on copper sulfate induced-emesis in young chicks.
Keywords
- Anti-emetic;
- Alpinia katsumadai Hayata (Zingiberaceae);
- (3R,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene