The Korean Journal of Physiology and Pharmacology
- Volume 3 Issue 6
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- Pages.579-586
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Effect of C1 Esterase Inhibitor on the Cardiac Dysfunction Following Ischemia and Reperfusion in the Isolated Perfused Rat Heart
- Lee, Geon-Young (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
- Shin, Yong-Kyoo (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
- Jang, Yoon-Young (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
- Song, Jin-Ho (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
- Kim, Dae-Joong (Department of Anatomy, College of Medicine, Kangwon National University)
- Published : 1999.12.21
Abstract
Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement- dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg) to I/R hearts in the presence of PMNs