The Korean Journal of Physiology and Pharmacology
- Volume 3 Issue 3
- /
- Pages.283-291
- /
- 1999
- /
- 1226-4512(pISSN)
- /
- 2093-3827(eISSN)
Selective Cytotoxicity of a Novel Platinum (II) Coordination Complex on Human Gastric Cancer Cell Lines and Normal Kidney Cells
- Jung, Jee-Chang (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Kim, Young-Kyu (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Yim, Sung-Vin (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Park, Seung-Joon (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Chung, Joo-Ho (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Chang, Sung-Goo (Departments of Urology, School of Medicine, Kyung Hee University) ;
- Lee, Kyung-Tae (Department of Biochemistry, College of Pharmacy, Kyung Hee University) ;
- Rho, Young-Soo (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
- Published : 1999.06.21
Abstract
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)]