The Korean Journal of Physiology and Pharmacology
- Volume 3 Issue 2
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- Pages.207-213
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Assessment of Flavin-containing Monooxygenase (FMO) Activity by Determining Urinary Ratio of Theobromine and Caffeine in a Korean Population after Drinking a Cup of Coffee
- Chung, Woon-Gye (Department of Pharmacology and Toxicology, Medicinal Toxicology Research Center, College of Medicine, Inha University) ;
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Kang, Ju-Hee
(Department of Pharmacology and Toxicology, College of Medicine, Inha University) ;
- Roh, Hyung-Keun (Department of Internal Medicine, College of Medicine, Inha University) ;
- Lee, Kyung-Hoon (Department of Pharmacology and Toxicology, College of Medicine, Inha University) ;
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Park, Chang-Shin
(Department of Pharmacology and Toxicology, College of Medicine, Inha University) ;
- Cha, Young-Nam (Department of Pharmacology and Toxicology, Medicinal Toxicology Research Center, College of Medicine, Inha University)
- Published : 1999.04.21
Abstract
To examine individual variation in drug metabolism catalyzed by flavin-containing monooxygenase (FMO), 179 Korean volunteers' urinary molar concentration ratio of theobromine (TB) and caffeine (CA) was determined. Their urine was collected for 1 hr (between 4 and 5 hrs) after they drank a cup of coffee containing 115 mg CA and analyzed by an HPLC system. The lowest TB/CA ratio obtained was 0.40, the highest ratio was 15.17 (38-fold difference), and the median ratio for all subjects was 1.87. The mean was 2.66 with 2.36 S.D.. In 134 nonsmokers, the mean ratio was