The Korean Journal of Physiology and Pharmacology
- 제3권1호
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- Pages.69-74
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Systemic Injection of Lidocaine Induce Expression of c-fos mRNA and Protein in Adult Rat Brain
- Chae, Han-Jung (Department of Dental Pharmacology, Wonkwang University School of Dentistry) ;
- Kang, Jang-Sook (Department of Dental Pharmacology, Wonkwang University School of Dentistry) ;
- Cho, Seoung-Bum (Department of Dental Pharmacology, Wonkwang University School of Dentistry) ;
- Jin, Byung-Gwan (Department of Biochemistry, Kyunghee University School of Medicine) ;
- Won, Suk-Jun (Department of Pharmacology, Ajou University School of Medicine) ;
- Gwag, Byung-Joo (Department of Pharmacology, Ajou University School of Medicine) ;
- Kim, Hyung-Ryong (Department of Dental Pharmacology, Wonkwang University School of Dentistry)
- 발행 : 1999.02.21
초록
Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using