The Korean Journal of Physiology and Pharmacology
- Volume 3 Issue 1
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- Pages.29-34
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Cholinergic Activity Related to Cardiovascular Regulation in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats
- Lee, Seok-Yong (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Lee, Sang-Bok (Department of Pharmacology, Catholic University Medical College)
- Published : 1999.02.21
Abstract
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to clarify the mechanisms of cholinergic hyperactivity in RVLM of the SHR, we studied the activities of enzymes that participate in the biosynthesis and degradation of acetylcholine (ACh) and the density of muscarinic receptors in RVLM of the 14- to 18-week-old SHR and age-marched Wistar Kyoto rats (WKY). Choline acetyltransferase activity was far greater in RVLM of SHR than that of WKY.