Journal of Oriental Physiology (동의생리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Acori Rhizoma water extract on the Cerebral Cortex Neuron injured by Glucose Oxidase

석창포(石菖蒲) 전탕액(煎湯液)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)

  • Choi, Kong-Han (Dept. of Psycology, College of Oriental medicine, Wonkwang University) ;
  • Park, Seung-Taeck (Dept. of Anatomy, College of medicine, Wonkwang University) ;
  • Ryu, Do-Gon (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Choi, Min-Ho (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Hea, Jin-Young (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Kang, Sung-Do (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Go, Jeong-Soo (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Yang, Sang-cheal (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Sung, Yeun-Kyung (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Cho, Nam-Su (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Lee, Chun-Woo (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Sou, Eui-Suk (Dept. of Physiology, College of Oriental medicine, Wonkwang University) ;
  • Ryu, Young-Su (Dept. of Psycology, College of Oriental medicine, Wonkwang University)
  • 최공한 (원광대학교 한의과대학 정신과교실) ;
  • 박승택 (원광대학교 의과대학 해부학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 최민호 (원광대학교 한의과대학 생리학교실) ;
  • 허진영 (원광대학교 한의과대학 생리학교실) ;
  • 강성도 (원광대학교 한의과대학 생리학교실) ;
  • 고정수 (원광대학교 한의과대학 생리학교실) ;
  • 양상철 (원광대학교 한의과대학 생리학교실) ;
  • 성은경 (원광대학교 한의과대학 생리학교실) ;
  • 조남수 (원광대학교 한의과대학 생리학교실) ;
  • 이춘우 (원광대학교 한의과대학 생리학교실) ;
  • 서의석 (원광대학교 한의과대학 생리학교실) ;
  • 류영수 (원광대학교 한의과대학 정신과교실)
  • Published : 1999.09.01
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Abstract

The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay. 2. GO, a oxygen radical, decreased the amount of neurofilaments and total protein. 3. AR have efficacy of increasing the amount of neurofilament. 4. AR have efficacy of increasing the amount of total protein. From the above results, It is concluded that AR has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And AR is thought to have certain pharmacological effects on controlling over aging. Further clinical study of this pharmacological effects of AR should be complemented.

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