Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Teratogenic Effect of Carbamazepine

카바마제핀의 기형발생 효과

  • Choi, Yeong-Tae (Department of Psychiatry, Pusan Dong In Hospital) ;
  • Cheon, Jin-Sook (Department of Neuropsychiatry, Kosin University, School of Medicine)
  • 최영태 (부산동인병원 정신과) ;
  • 전진숙 (고신대학교 의과대학 신경정신과학교실)
  • Published : 1998.12.25
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Abstract

The mother was 24 years old, primipara, and had been taking carbamazepine 400mg(serum concentration $5.0-8.5{\mu}g/ml$) during pregnancy without any clinical seizures. A male baby with physical malformation was delivered on week 39. The malformation is extradigit(polydactily) on X-ray of right foot and left mild hydronephrosis on ultrasonography and renal scan with radioactive material. We reported this rare case and reviewed related articles about teratogenic effect of carbamazepine, mechanism of action and prevention of teratogenesis.

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