생물정신의학 (Korean Journal of Biological Psychiatry)
- 제5권2호
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- Pages.184-196
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- 1998
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
전전두피질과 정신분열병
Prefrontal Cortex and Schizophrenia
- Chung, Young-Chul (Department of Psychiatry, School of Medicine, Chonbuk National University, Institute for Medical Sciences) ;
- Eun, Hong-Bae (Department of Psychiatry, School of Medicine, Chonbuk National University, Institute for Medical Sciences)
- 발행 : 1998.12.25
초록
With a rapid development of neuroscience, the theories related to the pathophysiology of schizophrenia have been changed a lot from a simple hyperdopaminergic one to the various complicated ones. Among these, the theories regarding prefrontal cortex(PFC) pathology as a cause of schizophrenia are gaining more recognition as the results of neuroimaging and neuropsychological tests in schizophrenia consistently report abnormalities in PFC. Therefore, we first reviewed the unique characteristics of PFC in anatomy, neurochemistry and neurophysiology to enhance an understanding of those ones. Secondly, various neurotransmitter, neurodevelopmental and neural network theories of schizophrenia introduced recently were reviewed in terms of PFC pathology.