Tuberculosis and Respiratory Diseases
- 제45권5호
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- Pages.1047-1057
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- 1998
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
유육종증환자의 기관지폐포세척액내 Interleukin에 대한 연구
Interleukin Levels in the Bronchoalveolar Lavage Fluid of Patients with Pulmonary Sarcoidosis
- 송정섭 (가톨릭대학교 의과대학 내과학교실) ;
- 안중현 (가톨릭대학교 의과대학 내과학교실) ;
- 김치홍 (가톨릭대학교 의과대학 내과학교실) ;
- 김관형 (가톨릭대학교 의과대학 내과학교실) ;
- 문화식 (가톨릭대학교 의과대학 내과학교실) ;
- 박성학 (가톨릭대학교 의과대학 내과학교실)
- Song, Jeong-Sup (Department of Internal Medicine, Catholic University of Korea, College of Medicine) ;
- Ahn, Joong-Hyun (Department of Internal Medicine, Catholic University of Korea, College of Medicine) ;
- Kim, Chi-Hong (Department of Internal Medicine, Catholic University of Korea, College of Medicine) ;
- Kim, Kwan-Hyoung (Department of Internal Medicine, Catholic University of Korea, College of Medicine) ;
- Moon, Hwa-Sik (Department of Internal Medicine, Catholic University of Korea, College of Medicine) ;
- Park, Sung-Hak (Department of Internal Medicine, Catholic University of Korea, College of Medicine)
- 발행 : 1998.10.30
초록
연구배경: 유육종증은 전신을 침범하는 만성 육아종성 질환으로 단핵구성 폐포염이 선행되어 육아종형성을 유도하며, 여러 종류의 cytokine들이 육아종성 염증과 그에 따른 섬유화의명태생리가전에 관여한다고 알려져 있다. 특히 최근에는 IL-6와 IL-8이 유육종증에서 광범위하게 염증반응을 진행시키는 것으로 보고되고 있고, 반면에 IL-10은 단핵구/대식세포와 T림프구의 기능을 억제하여 IL-1, IL-6, TNF-
Background : Sarcoidosis is a systemic granulomatous disorder of unknown origin and characterized by accumulation of T cells and macrophages. Various cytokines may play crucial roles in the activation of T cells and macrophages, and thereby in the formation of granulomas. However, little is known about the balance between proinflammatory cytokines and antiinflammatory cytokines in the development of sarcoid granulomas and disease activities. In the present study, we measured IL-6, IL-8 and IL-10 in the bronchoalveolar lavage fluid(BALF) from patients with pulmonary sarcoidosis to find out whether there is an imbalance between proinflammatory cytokines and antiinflammatory cytokines in the lung. Methods: Fourteen subjects with the diagnosis of sarcoidosis and six healthy volunteers were included. BALF was concentrated ten-fold by pressure ultrafiltration and each cytokine levels were measured by EUSA method. Active sarcoidosis was defined by major organ involvement or clinically progressive diseases. Results: The mean IL-6 levels in the BALF of the active sarcoidosis group were significantly increased than in controls or inactive sarcoidosis group(p<0.05). Meanwhile, the IL-8 levels were increased and IL-10 levels were decreased in the active sarcoidosis group than in controls or inactive sarcoidosis group without significance(p>0.05). In active pulmonary sarcoidosis patients, the IL-6 levels in BALF correlated with the BALF CD4/CD8 ratio(r=0.768, p<0.05) and IL-8 levels(r=0.564, p<0.05). Conclusions : The data presented showed that pro-inflammatory cytokine IL-6 is important in the pathogenesis of sarcoidosis and decreased tendency of anti-inflammatory cytokine IL-10 might also be involved in the development of granulomatous inflammation in sarcoidosis.