Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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The Radiation Sensitizer Effect of $TNF-{\alpha}$ on Heterotransplanted Human Squamous Cell Carcinoma

이종이식된 인체 편평상피세포암에 대한 종양괴사인자의 방사선감작효과에 대한 연구

  • Chung Phil-Sang (Department of Otolaryngology-Head and Neck Surgery, Dankook University, College of Medicine) ;
  • Kim Han-Gyun (Department of Therapeutic Radiology, Dankook University, College of Medicine) ;
  • Yun Hyong-Geun (Department of Therapeutic Radiology, Dankook University, College of Medicine)
  • 정필상 (단국대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김한균 (단국대학교 의과대학 치료방사선과학교실) ;
  • 윤형근 (단국대학교 의과대학 치료방사선과학교실)
  • Published : 1998.11.01
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Abstract

Background and Objectives: Numerous studies were conducted to develop radiosensitizers to increase antitumor effect and decrease systemic toxicity of ionizing radiation. In current study, the authors tested the synergistic effect of mutant $TNF-{\alpha}(M_3S)$ with radiation therapy on heterotransplanted hypoparyngeal squamous cell carcinoma. Materials and Method: SNU-1041 cell line was heterotransplanted to nude mice. When the tumors grew up to $70mm^3$ or more, the animals were randomly placed into 4 groups(n=10/group). Group I : 0.1ml of normal saline injected intraperitoneally once a day for 5 days. Group II : 10ug of $TNF-{\alpha}$ injected intraperitoneally once a day for 5 days. Group III : a single radiation dose of 10 Gy per animal delivered. Group IV : single radiation dose of 10 Gy was delivered 1 hour after intraperitoneal injection of $TNF-{\alpha}$ 10 ug. Results: Four weeks after treatment, group IV showed the least tumor growth during the 4 weeks follow up and the relative tumor growth rate(RTG) of each groups after 4 weeks were 31, 5.8, 10, and 3.2 respectively(p<0.05). Conclusion: These study suggests that pretreatment with $TNF-{\alpha}$ can significantly enhance the effects of radiation therapy and further studies may be needed for clinical trials of combination treatment of $TNF-{\alpha}$ and radiation.

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