Journal of Yeungnam Medical Science
- 제15권1호
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- Pages.173-181
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- 1998
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- 2799-8010(eISSN)
리팜핀에 의한 급성 신부전
A Case of Rifampin-induced Acute Renal Failure
- 이동화 (포항성모병원 내과) ;
- 박태규 (포항성모병원 내과) ;
- 이재성 (포항성모병원 내과) ;
- 김희식 (포항성모병원 내과) ;
- 김경현 (포항성모병원 내과) ;
- 하영준 (포항성모병원 내과) ;
- 정성복 (포항성모병원 내과) ;
-
도준영
(영남대학교 의과대학 내과학교실) ;
- 윤경우 (영남대학교 의과대학 내과학교실)
- Lee, Dong-Hwa (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Park, Te-Gue (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Lee, Je-Sung (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Kim, Heui-Sik (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Kim, Kyoung-Hyun (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Ha, Young-Jun (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
- Jung, Sung-Bok (Department of Internal Medicine, Pohang St. Mary's Hospital) ;
-
Do, Jun-Young
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Yoon, Kyung-Woo (Department of Internal Medicine, College of Medicine, Yeungnam University)
- 발행 : 1998.06.30
초록
Rifampin is common drug to treat tuberculosis. Rifampin induced acute renal failure, hemolytic anemia and thrombocytopenia is rare and severe complication. We have experienced a case of rifampin induced acute renal failure, hemolytic anemia and thrombocytopenia. Forty-six years old male was suffered from reactivation of pulmonary tuberculosis, and had to medicate antituberculosis drugs including rifampin(600mg/day). Seven years ago, antituberdulosis medication were successfully administered to treat pulmonary tuberculosis without any side effects of drugs. But eight days after readministration of rifampin, fever, abdominal pain, vomiting, oliguria, elevated BUN and creatinine were developed. And thrombocytopenia was also identified after administration of rifampin. The patient was recovered slowly after discontinuation of rifampin & intensive medical care. The renal function was normalized at 55 days after cessation of rifampin. The renal pathologic findings were interstitial nephritis and acute tubular necrosis. And, the rifampin dependent antibodies were identified by indirect antiglobulin test in the presence of rifampin. So we report this case with a brief review of literature.