Journal of Yeungnam Medical Science
- 제15권1호
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- Pages.55-66
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- 1998
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- 2799-8010(eISSN)
한탄바이러스의 섬유아세포 감염에 대한 Integrin 항체의 억제 효과
The Suppressive Effects of Integrin Antibodies on the Infection of Hantaan Virus in Fibroblasts
- Park, Ho-Sun (Department of Microbiology College of Medicine, Yeungnam University) ;
- Kim, Ki-Duk (Department of Microbiology College of Medicine, Yeungnam University) ;
- Kim, Sung-Kwang (Department of Microbiology College of Medicine, Yeungnam University)
- 발행 : 1998.06.30
초록
사람과 동일한 증상을 나타내는 동물 모델이 없는 신증후출혈열의 병리 기전을 이해하기 위하여 in vitro culture system을 이용하였다. 신증후출혈열의 주된 병변이 혈관내피세포외에 섬유아세포가 많이 존재하는 신세뇨관 간질 및 폐간질임을 기초로 하여 계태아와 Mongolian gerbil의 섬유아세포에서 fibronectin에 대한 수용체인
Pathophysiological mechanism of hemorrhagic fever with renal syndrome (HFRS) is not fully understood. Major clinical findings of HFRS patients are widespread hemorrhage, acute renal failure and shock. Basic lesion is vascular injury with microvascular hemorrhage and relatively little inflammation. According to autopsy findings, renal medulla shows focal hemorrhage, tubular necrosis and interstitial mononuclear infiltrates. The predominant cell type in the renal and pulmonary interstitium is a fibroblast and it participates in the healing process at the injury site by secreting a large amount of extracellular matrix proteins. Cultured human lung fibroblasts and Mongolian gerbil fibroblasts were known to be good host cells for the hantaan virus. It is possible that not only the endothelial cell but also the fibroblast is a target of Hantaan virus and the fibroblast might be involved in the pathogenesis and the healing process in HFRS. Integrins are adhesion molecules, and act as receptors for many extracellular matrix proteins. Recently, there are many reports that cell surface integrins influence on some viral infections or reversely viruses influence on the expression of integrins. The