Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)
- Volume 8 Issue 2
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- Pages.289-295
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- 1998
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- 2384-132X(pISSN)
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- 2289-0564(eISSN)
Adverse Effects of Kerosene Cleaning on the Formation of DNA Adducts in Skin and Lung of Mice Dermally Exposed to Used Gasoline Engine Oil
피부에 폭로된 폐가솔린엔진오일의 표적장기 DNA adducts형성과 케로신의 세척효과에 관한 연구
- Lee, Jin Heon (Department of Occupational Safety and Health, Inje University) ;
- Talaska, Glenn (Department of Environmental Health, University of Cincinnati)
- Published : 1998.11.13
Abstract
Used gasoline engine oils(UGEO) are carcinogenic in long term studies and capable of increasing the number of carcinogen-DNA adducts in short term studies when dermally applied to mice. The carcinogenic risk of UGEO has been attributed to the concentration of polycyclic aromatic hydrocarbons(PAH) which accumulate in the lubricating system during the combustion of gasoline. When dermally exposed to UGEO, the use of hand cleanser was commonly recommended for removing it. But generally workers who dermally exposed oils, use kerosene as cleaner which make skin trouble. During this study, female mice aged 4-6 weeks were utilized to evaluate the efficiency of kerosene, as solvent-based cleanser, following dermal exposure to UGEO. DNA adduct were detected at skin and lung tissues by using the