The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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Cytologic Findings of Infectious Mononucleosis Lymphadenitis - A Report of Four Cases -

전염성 단핵구중 림프절염의 세침흡인 세포학적 소견 - 4예 보고 -

  • Sohn, Jin-Hee (Department of Pathology, Hangang Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Jung, Eun-Ha (Department of Pathology, Hangang Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Park, Hye-Rim (Department of Pathology, Hangang Sacred Heart Hospital, College of Medicine, Hallym University)
  • 손진희 (한림의대 한강성심병원 해부병리과) ;
  • 정은하 (한림의대 한강성심병원 해부병리과) ;
  • 박혜림 (한림의대 한강성심병원 해부병리과)
  • Published : 1998.12.30
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Abstract

Infectious mononucleosis(IM) Is an acute self-limiting lymphoproliferative disorder associated with infection by the Epstein-Barr Virus(EBV), with the characteristic triad of fever, sore throat, and cervical or generalized lymphadenopathy. And also there are atypical lymphocytes in the peripheral blood. Cytological findings of IM lymphadenitis are characterized by a florid immunoblastic and atypical lymphoid cell proliferation. However, the small number of cases were studied by fineneedle aspiration cytology(FNAC) even though there was a complexity of lymph node pathology. It is important to recognize the reactive pattern of IM that would initiate EBV study and to avoid unnecessary biopsy We studied findings of lymph node FNAC from 4 patients with EBV infection confirmed by EBV-specific serologic studios. All of the cases were positive for viral capsid antigen(VCA) and one case was positive for anti-EBV nuclear antigen(EBNA). Cytologically, all of the cases exhibited high cellularity and atypia with great numbers of large immunoblastic lymphocytes.

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