Applied Microscopy

Korean Society of Microscopy (한국현미경학회)
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Morphological Changes in Glomerular Podocytes in Puromycin Aminonucleoside Induced Nephropathy

Puromycin Aminonucleoside 투여로 인한 사구체 족세포의 초미형태학적 변화

  • Kim, Young-Ho (Department of Central Electron Microscopy, Keimyung University School of Medicine) ;
  • Park, Kwan-Kyu (Department of Pathology, Keimyung University School of Medicine) ;
  • Kim, Young-Man (Department of Clinical Pathology, Yeungnam Hospital) ;
  • Cho, Soo-Yeul (Department of Food and Nutrition, Yeungnam University)
  • 김영호 (계명대학교 의과대학 중앙전자현미경실) ;
  • 박관규 (계명대학교 의과대학 병리학교실) ;
  • 김영만 (영남대학교병원 임상병리과) ;
  • 조수열 (영남대학교 식품영양학과)
  • Published : 1998.12.01
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Abstract

Puromycin aminonucleoside (PAN) nephropathy was induced in a group of Sprague-Dawley rat by a single dose of intraperitoneal Injection to study an ultrastructural change of glomerulus. The experimental rats developed proteinuria three days after PAN injection. Electron microscopic studies of glomeruli showed the loss of epithelial foot processes, formation of cytoplasmic vacuoles, microvillous formation and increased numbers of lysosomes in the cytoplasm of podocytes. It is strongly suggested that proteinuria in PAN nephrosis may be primarily due to a glomerular epithelial lesion, leading to focal disarray of anionic sites or focal defects in the epithelial covering of the basement membrane. The loss of anionic sites in the basement membrane nay be caused by the foot process fusion and the epithelial detachment from the basement membrane.

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