Applied Microscopy

Korean Society of Microscopy (한국현미경학회)
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Ultrastructural Localization of Mercury in Spleen of the Mouse

마우스 비장내 수은의 미세구조적 위치

  • Cho, Hyun-Wook (Dept. of Biology, College of Natural Sciences, Sunchon National University) ;
  • Kim, Myung-Hoon (Dept. of Physical Therapy, Kwangju Health College) ;
  • Yee, Sung-Tae (Dept. of Biology, College of Natural Sciences, Sunchon National University)
  • 조현욱 (순천대학교 자연과학대학 생물학과) ;
  • 김명훈 (광주보건전문대학 물리치료과) ;
  • 이성태 (순천대학교 자연과학대학 생물학과)
  • Published : 1998.12.01
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Abstract

The autometallographic method was used to demonstrate the localization of mercury deposits in spleen of mouse. The mercury deposits were identified with the light and electron mocroscope. Mice were treated with methylmercuric chloride in the drinking water (demineralized water) for 40 days. Control and mercury treated groups showed no significant differences in mean body weight and spleen weight per one mouse. Mercury grains were appeared in the germinal center of white pulp consist of a preponderancing lymphocytes, not in red pulp and capsule. At the ultrastructural level, mercury deposits were restricted to lysosomes of macrophage and lymphocyte. Specially, volume in lysosomes of the macrophage was increased. These results suggest that mercury localization in lysosomes is associated with the change of immune activity.

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