Toxicological Research
- Volume 14 Issue 3
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- Pages.321-328
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Effect of Hepatic Damage on the Toluene Metabolism in Carbon Tetrachloride Pretreated-Rats
흰쥐에 있어서 톨루엔 대사에 미치는 간손상의 영향
- Cha, Sang-Eun (Department of industrial Safety and Hygiene, Andong College) ;
- Yoon, Chong-Guk (Department of Public Health, College of Natural Science, Keimyung University) ;
- Lee, Sang-Il (Department of Food Science, Keimyung Junior College)
- Published : 1998.09.01
Abstract
This study was performed to evaluate the effect of liver damage on toluene metabolism in rats pretreated with carbon tetachloride. Liver damage in rats was induced by administration of 0.1ml of carbon tetrachloride per 100g of body wight intraperitoneally every day for four weeks except the last day before sacrifice. One day before sacrifice, toluene was administered to the animals instead of carbon tetrachloride. Rats were sacrificed at the 1st, the 2nd, the 3rd and the 4th week after the first administration of carbon tetachloride. Based on the histopathological findings, liver weight and serum alanine aminotransferase, the
Keywords
- Carbon tetrachloride;
- Toluene;
- Cytochrome P450;
- Benzylalcohol or aldehyde dehydrogenase;
- Hippuric acid