YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Renal Action of $N^G$-Nitro-L-arginine, Nitric Oxide Synthase Inhibitor, in Dog and Rabbit

니트릭옥사이드의 합성 억제제인 $N^G$-니트로-L-아르기닌의 신장작용

  • Published : 1998.10.01
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Abstract

This study was performed in order to investigate the effect of renal function of NG-nitro-L-arginine (L-NOARG), inhibitor of nitric oxide (NO) synthase, in dog and ra bbit. L-NOARG, when given intravenously in dogs, exhibited the decrease in urine flow (vol), renal plasma flow (RPF), osmolar clearance ($C_{osm}$) and amounts of sodium and potassium excreted in urine($E_{Na},\;E_K$). These renal functions of L-NOARG showed the same aspect in rabbit, too. L-NOARG, when administered into a renal artery, showed the same pattern as was obtained when given intravenously in both experimental and control kidney in dog. L-NOARG administered into the carotid artery showed the decrease in Vol, RPF, $E_{Na}$, in a low doses that did not show any effect when given intravenously. Above results suggest that L-NOARG produces antidiuretic action in dog and rabbit, and these antidiuretic actions may be mediated by central action.

Keywords

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