YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Glycyrrhizin on Apoptosis of Transplanted-L1210 cells in mice

글리시르히진이 생쥐에 이식된 L1210 세포의 아포프토시스에 미치는 영향

  • 은재순 (우석대학교 약학대학) ;
  • 권진 (우석대학교 약학대학) ;
  • 오찬호 (우석대학교 자연과학대학)
  • Published : 1998.06.01
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Abstract

These experiments were conducted to investigate effects of glycyrrhizin (GL) on apoptosis of transplanted-L1210 cells in mice. GL induced apoptosis of transplanted-Ll2lO cells. GL increased nitric oxide production from peritoneal macrophages of L1210 cells-transplanted mice. NOC12, nitric oxide donor, induced apoptosis of L1210 cells in vitro. The apoptosis of L1210 cells were enhanced by co-culture of the peritoneal macrophages of GL-administered mice and L1210 cells in vitro, and was inhibited by L-NMMA. These results suggest that the apoptosis of transplanted-Ll2lO cells is partly induced by nitric oxide produced from peritoneal macrophages in GL-administered mice.

Keywords

References

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