YAKHAK HOEJI (약학회지)
- Volume 42 Issue 3
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- Pages.275-283
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- 1998
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Pharmacokinetics, Cell Toxicity, Antitumor Activity and Spleen/Blood Cell Toxicity of Aclarubicin-entrapped Liposomes
리포좀에 봉입된 아클라루비신의 약물동태, 세포독성, 항암효과 및 비장/혈구 세포독성
- Park, Mork-Soon (DongKook Pharm. Do. Ltd.) ;
- Park, Jin-Kyu (DongKook Pharm. Do. Ltd.) ;
- Lee, Gye-Won (College of Pharmacy, Chungnam National University) ;
- Myung, Pyung-Keun (College of Pharmacy, Chungnam National University) ;
- Sok, Dai-Eun (College of Pharmacy, Chungnam National University) ;
- Hwang, Sung-Joo (College of Pharmacy, Chungnam National University) ;
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
- 박목순 (동국제약 주식회사) ;
- 박진규 (동국제약 주식회사) ;
- 이계원 (충남대학교 약학대학) ;
- 명평근 (충남대학교 약학대학) ;
- 석대은 (충남대학교 약학대학) ;
- 황성주 (충남대학교 약학대학) ;
- 지웅길 (충남대학교 약학대학)
- Published : 1998.06.01
Abstract
Aclarubicin(ACL)-entrapped freeze dried liposomes were prepared using Microfludizer to attain a sustained release at targeted organs in a prolonged time so that it can reduce th e side effect and maximize the therapeutic effect. The freeze-dried liposomes were evaluated for pharmacokinetics, antitumor activity against Sarcoma 180, cytotoxicity against L1210 and A549 tumor cells, spleen toxicity and myelosuppressive action. The
Keywords
- Aclarubicin microfluidizer;
- pharmacokinetics;
- cytotoxicity;
- freeze;
- dried liposome;
- antitumor activity;
- myelosuppression