YAKHAK HOEJI (약학회지)
- Volume 42 Issue 6
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- Pages.583-588
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- 1998
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Effect of Glycyrrhetinic acid on the Cell Death of Transplanted-Ll2lO cells in Mice
글리실레틴산이 생쥐에 이식된 L1210 세포의 세포사에 미치는 영향
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Eun, Jae-Soon
(College of Pharmacy, Woosuk University) ;
- Kwon, Jin (College of Pharmacy, Woosuk University) ;
- Yum, Jung-Yul (College of Pharmacy, Woosuk University) ;
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Oh, Chan-Ho
(College of Natural Science, Woosuk University)
- Published : 1998.12.01
Abstract
These experiments were investigated effects of the cell death of glycyrrhetinic acid (GA) on transplanted-L1210 cells in BALB/c mice. The GA suppressed the proliferation of L121 0 cells in vivo and in vitro system. The administration of GA induced apoptosis of transplanted-L1210 cells via the reduction of mitochondrial transmembrane potential in mice. The GA enhanced the production of nitric oxidation in peritoneal macrophages obtained from L1210 cells-transplanted mice. The apoptosis of L1210 cells were induced by co-culture of the macrophages obtained from GA administered mice and L1210 cells in vitro, and was partly inhibited by the treatment of L-NMMA. These results suggest that GA induces the cytotoxicity and the apoptosis of transplanted-L1210 cells via the production of nitric oxide in peritoneal macrophages.
Keywords
- glycyrrhetinic acid;
- apoptosis;
- mitochondrial transmembrane potential;
- macrophage;
- nitric oxide;
- cytotoxicity