YAKHAK HOEJI (약학회지)
- Volume 42 Issue 6
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- Pages.567-571
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- 1998
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
A Suppressive Component on Phagocytosis of Murine Peritoneal Macrophage in Aurantii immaturi pericarpium
청피에 함유된 복강 마크로파지의 탐식작용 억제 성분
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Eun, Jae-Soon
(College of Pharmacy, Woosuk University)
;
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- So, June-No (College of Natural Science, Woosuk University) ;
- Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
- Published : 1998.12.01
Abstract
The phagocytic activity of murine peritoneal macrophage, was determined by lucigenin chemiluminescence and engulfment of fluorescein-conjugated E. coli particle. The acti vity-guided fractionation upon the methylenechloride fraction of Aurantii immaturi pericarpium led to the isolation of a flavonoid, isosinensetin, as a suppressive component of phagocytosis. Isosinensetin suppressed the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and enhanced the production of nitric oxide in murine peritoneal macrophage.
Keywords
- Aurantii immaturi pericarpiumum;
- Phagocytosis;
- Macrophage;
- Chemiluminescence;
- Isosinensetin;
- FITC-conjugated E.coli